发明名称 |
BETA-ADRENERGIC ANTAGONIST COMPOUNDS AND DERIVATIVES OF BETA-ADRENERGIC ANTAGONISTS |
摘要 |
Molecular structures of beta -adrenergic antagonists are modified to produce biologically active compounds. The beta -antagonists are modified to form molecules of the general structure: <CHEM> wherein R is most generally R sec -OCH2-, and in some instances is R sec -, and R sec = an aryl or substituted aryl moiety; R min = -H, -CH3, or a short chain alkyl moiety; and Y = -OH, or more usually, -OAX or -NHAX, where A = an alkyl, aryl, or aralkyl moiety, and X = a terminal grouping, such as -CH3, -CF3 or -(CH2)nCOOH; or AX may be a carrier moiety consisting of a defined peptide or protein. |
申请公布号 |
DE3475615(D1) |
申请公布日期 |
1989.01.19 |
申请号 |
DE19843475615 |
申请日期 |
1984.02.02 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
GOODMAN, MURRAY;MARR-LEISY, DEBRA;ROSENKRANZ, ROBERTO PEDRO;MELMON, KENNETH LLOYD;VERLANDER, MICHAEL STEPHEN |
分类号 |
A61K31/16;A61K31/165;A61K31/195;A61K31/22;A61K38/00;A61P25/02;C07C67/00;C07C227/00;C07C229/12;C07C235/74;C07C237/04;C07C237/06;C07C237/12;C07C237/22;C07C237/42;C07C239/00;C07C275/38;C07D209/08;C07D209/48;C07D285/10;C07D303/22;C07D303/24;C07D405/12;C07K5/065;(IPC1-7):C07C103/50;C07C103/76;C07C101/30;C07C127/19;C07C143/74;C07K5/02 |
主分类号 |
A61K31/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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