Rubella E1 glycoprotein antigens.

摘要

A small portion of the E1 peptide of rubella virus which contains three epitopic sites is identified. This portion of the peptide is useful as a basis for standard antigenic peptides for rubella diagnosis and vaccination. The inventors have produced the major rubella envelope antigen E1 and a fragment of it by genetic expression in E.coli. The expressed products show good reactivity with E1 monoclonal and rubella specific human Ig antibodies and also have potential as immunising agents.