| 摘要 |
NEW MATERIAL:An optically active diphosphine ligand shown by the formulaI (R<1> and R<2> are substituted or unsubstituted aryl; R<3> is H, alkyl, etc.; R<4> is H, amino acid residue, peptide residue; X is H, amino-protecting group; R<3> and R<4> are capable of forming substituted or unsubstituted polymethylene group; * is optically active point). EXAMPLE:(2S, 4S)-N-(N'-Benzyloxycarbonyl-L-phenylalanyl)-4-diphenylphosphino- 2-diphenylphosphinomethylpyrrolidine. USE:Forming a complex (e.g., rhodium complex) serving as an asymmetric catalyst useful in preparing an optically active alpha-amino acid or peptides. PROCESS:An optically active pyrrolidinodiphosphine shown by the formula II is reacted with an amino acid shown by the formula II or peptide in the presence of a binder (e.g., dicyclohexylcarbodiimide), to give a ligand shown by the formulaI. |
