| 摘要 |
The invention provides compositions and methods for improved identification of individuals and individual members of species, by use of regions of DNA hypervariability found in all cells, otherwise called hypervariable regions, of HVRs, in which the DNa contains tandem repeats. The number of repeats varies considerably from the individual to another. Many such regions of the human genome can be probed simultaneously to display this variability using any DNA or other polynucleotide probe of which the essential constituent is a short core sequence, tandemly repeated at least 3 times. Probing with each of the probes reveals differences in genomic DNA at multiple highly-polymorphic hypervariable regions to produce an individual-specific DNA 'fingerprint' of general use for genetic identification purposes, paternity and maternity testing, testing of the relatedness of individuals and the relationship of one individual to another (i.e. family structure analysis), forensic medicine, the diagnosis of genetic diseases and cancer, assessment of bone marrow engraftment, study of pedigrees of non-human species, and identification of individual members of these species. Probing can be carried out on DNA from any cellular tissue. |
