| 摘要 |
Phenyl-3-aminoalkyl-4-methyl-2,6-dioxopiperidines of the Formula I <CHEM> wherein: R1 represents hydrogen or C1-C4 alkyl; n is 1 or 2; R2 represents hydrogen or methyl, provided that one R2 is hydrogen when n is 2; R3 represents hydrogen or C1-C2 alkyl; R4 represents C1-C2 alkyl; R5 and R6 independently represent hydrogen or methyl; m is 0 to 3; and each Y is in a meta or para position and independently represents hydroxy, C1-C2 alkoxy, C1-C2 alkyl, C1-C2 hydroxyalkyl, halogen, or trifluoromethyl, provided that hydroxy and alkoxy are not in the para position, and pharmacologically acceptable salts thereof antagonise anxiogenesis associated with withdrawal from addictive drugs, especially alcohol, cocaine and nicotine. The presently preferred compound is 3-(3 min methoxyphenyl)-3-(3 sec -N,N-dimethylaminopropyl) -4,4-dimethyl-2,6-dioxopiperidine (AGN 2979). |
