Stable, injectable solutions of vincristine salts.

摘要

A stable, injectable pharmaceutical composition of vinca dimer salts. The compositions are in the form of an aqueous solution comprising per 1 ml of solution: from about 0.2 to about 2 mg of one or more pharmaceutically acceptable vinca dimer salts; from aobut 0.1 to about 1.0 mg of a pharmaceutically acceptable ethylenediamine-tetraacetic acid (EDTA) salt; acetate buffer in an amount necessary to maintain said aqueous solution at a pH of from about 3.0 to about 5.5; and from about 1.5 to about 2.5 mg of a preservative selected from methyl paraben, propyl paraben and mixtures thereof.