摘要 |
<p>Compounds useful in treating cardiovascular disorders are the carboxylic acids depicted in formulas (1) and (2) (1) (2) as well as their pharmaceutically acceptable, non-toxic salts and esters, wherein: n is an integer from one to four; R1 is hydroxy; R2 is hydrogen; or R1 and R2 together are an oxo group; R3 is wherein A is -CH2-CH2-; trans-CH=CH-; -C?C-; and R4 is linear or branched alkyl of one to twelve carbons, preferably 1-10 carbons and most preferrably 3-8 carbons, cycloalkyl of three to eight carbons; phenyl optionally substituted with one or two identical substituents selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, trifluoromethyl, and halo; or optionally substituted phenylalkyl.</p> |