ANALGESIC PEPTIDE AND PROCESS FOR THE PREPARATION THEREOF

摘要

of the disclosure A novel peptide having the primary structure: N-Me-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D?Ile-Arg-Pro-Lys- D?Leu-Lys-Trp-NH2 (in which D?Ile and D?Leu represent a D-Ile and a D-Leu residue respectively, other abbreviations of amino acids represent each an L-amino acid residue and Me represents a methyl group), which exhibits a remarkable analgesic effect when administered peripherally. A process for the preparation thereof by a solid phase method is also disclosed.