摘要 |
A compound of formula (III) or physiologically acceptable salts thereof, wherein: Z is a bond, -O- or -NH-; R1 and R3 are independently selected from C5-12 substituted of unsubstituted hydrocarbon radicals; R2 is hydrogen or a C1-5 substituted or unsubstituted hydrocarbon radical; said substituted hydrocarbon radicals are substituted with physiologically innocuous substituents which do not interfere with the binding of said compound with elastase-type enzymes; provided that: when R1 is oxohexyl and R2 is hydrogen, then R3 cannot be pentyl; when R1 is oxoheptyl and R2 is hydrogen, then R3 cannot be hexyl; when R1 is oxononyl and R2 is hydrogen, then R3 cannot be octyl; when R1 is oxodecyl and R2 is hydrogen, then R3 cannot be nonyl; and when R1 is oxododecyl and R2 is hydrogen, then R3 cannot be undecyl. These compounds are potent and specific inhibitor compounds fo elastase-type enzymes, especially for human leucocytic elastase (HLE) and can be expected to be useful in the treatment of elastase-type implicated diseases such as arthritis, tumor growth and emphysema. Production, method of use and pharmaceutical compositions containing these compounds are disclosed. |