PSEUDORABIES VIRUS RECOMBINANTS AND THEIR USE IN THE PRODUCTION OF PROTEINS

摘要

A recombinant pseudorabies virus comprising: a pseudorabies virus genome optionally having at least a portion of at least one nonessential region deleted therefrom; and a foreign DNA fragment coding for a desired protein and capable of being expressed, wherein the foreign DNA fragment is inserted in the pseudorabies virus genome at a point selected from within a nonessential XhoI/gIII region of the genome. The insertion may be made at an EcoRI site generated at a point within a non-essential XhoI/gIII region of the genome. The recombinant virus may be used as a vaccine, or may be used to infect host cells for the production of said desired protein.