N-aminoalkylperfluoroalkanoylaminobenzene-sulfonamide anti-arrhythmic agents

摘要

N-Aminoalkyl(perfluoroalkanoylaminophenyl)sulfonic acid amides of the formula: <IMAGE> in which R1 is perfluoroalkanoylamino of 2 to 4 carbon atoms, in 3- or 4- position of the benzene ring; R2 is hydrogen or alkyl of 1 to 4 carbon atoms; R3 is hydrogen or straight or branched chain alkyl of 1 to 4 carbon atoms; R4 is straight or branched chain alkyl of 1 to 4 carbon atoms; and n is one of the integers 2, 3 or 4; or a pharmaceutically acceptable salt thereof, are Class I anti-arrhythmic agents useful in the treatment of cardiac arrhythmias and conditions characterized by coronary arteries vasospasm and myocardial ischemia.