发明名称 |
PROCESS FOR PREPARATION OF N7-AMIDINO SUBSTITUTED MITOMYCIN C DERIVATIVES |
摘要 |
<p>There is disclosed a process for the preparation of N7-amidino substituted mitomycin C derivatives. The process comprises reacting mitomycin C or an N1a substituted derivative thereof such as porfiromycin with a chloroformimidinium salt in a polar solvent at low temperature. This reaction is conducted in the presence of a tertiary amine. This process eliminates the need for a strong base such as NaH prior to addition of a chlorofomimidinium salt.</p> |
申请公布号 |
CA1247617(A) |
申请公布日期 |
1988.12.27 |
申请号 |
CA19860501609 |
申请日期 |
1986.02.11 |
申请人 |
BRISTOL-MYERS COMPANY |
发明人 |
KANEKO, TAKUSHI;WONG, HENRY S.L. |
分类号 |
C07D487/14;(IPC1-7):C07D487/14 |
主分类号 |
C07D487/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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