发明名称 |
Method for the preparation of conjugates of adenine-9-beta-arabinofuranoside 5' monophosphate with lactosaminated human albumin, the obtained conjugates and therapeutically active compositions containing them |
摘要 |
For the preparation of conjugates of adenine-9-beta-D-arabinofuranoside 5'monophosphate (ara-AMP) with lactosaminated human albumin (L-HSA) aqueous solutions of the two components to be conjugated are brought into contact in the presence of 1-ethyl-3-(dimethylaminopropyl)-carbodiimide, by adjusting the pH in the range from slightly acidic to alkaline and by carrying out the conjugate separation. The resulting conjugate, wherein the molar ratio, as determined through spectrophotometric route, between ara-AMP and L-HSA does vary between 5 and 20, remains soluble after lyophilization even at room temperature and shows biological activity at least equivalent to that of the conjugate as prepared according to the known art.
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申请公布号 |
US4794170(A) |
申请公布日期 |
1988.12.27 |
申请号 |
US19850807657 |
申请日期 |
1985.12.11 |
申请人 |
LABORATORI BALDACCI SPA |
发明人 |
FIUME, LUIGI;BUSI, CORRADO;MATTIOLI, ALESSANDRO;BALDACCI, MASSIMO |
分类号 |
C07K14/76;A61K38/00;A61K38/16;A61K38/38;A61K47/48;A61P31/12;C07H19/20;C07K1/113;C07K14/00;(IPC1-7):C07D15/06 |
主分类号 |
C07K14/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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