| 摘要 |
PURPOSE:To obtain the titled compound useful as a synthetic intermediate for pharmaceuticals, nutrients, etc., in high purity and yield, by reacting epichlorohydrin with a cyanide under weakly basic condition. CONSTITUTION:Epichlorohydrin is made to react with a cyanide in a mixture of water and alcohols under weakly basic condition (pH8.0-10.0) at 20-25 deg.C for 1.5-4hr to obtain the objective (R)-4-chloro-3-hydroxybutyronitrile as a colorless oily substance. The cyanide is preferably potassium cyanide or sodium cyanide and the acid is preferably acetic acid. The objective compound can be converted to a high-purity (R)-carnitine by reacting the trimethylamine and hydrolyzing the an acid. Furthermore, it can be converted to (R)-4-amino-3- hydroxybutyric acid by reacting the ammonia and hydrolyzing with an acid. The produced compounds have cerebral metabolism improving action, cerebral blood flow increasing action, hypotensive action, sedative action, etc.
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