发明名称 |
A FACTOR VIII:C-LIKE MOLECULE WITH COAGULATING ACTIVITY |
摘要 |
A mutant of factor VIII : C in which the amino acids Ser<7><4><1> to Arg<1><6><8><9> are absent from the new molecule consequently retains of the 4 thrombin cleavage sites which have hitherto been regarded as essential only the cleavage site at Arg<3><7><2>. The cleavage site at Arg<1><6><4><8> is absent, and the amino acids adjacent to the cleavage sites at Arg<7><4><0> and Arg<1><6><8><9> are present, and linkage thereof produces a new cleavage site. The protein has a procoagulant activity and biological half-life very similar to that of the authentic protein and, moreover, is more rapidly activated by thrombin. <IMAGE> |
申请公布号 |
AU1810388(A) |
申请公布日期 |
1988.12.22 |
申请号 |
AU19880018103 |
申请日期 |
1988.06.17 |
申请人 |
BEHRINGWERKE AKTIENGESELLSCHAFT |
发明人 |
KLAUS-DIETER LANGNER;EGON AMANN;HANS KUPPER;GERD ZETTLMEISSL;BERNHARD HUBER |
分类号 |
C07K14/745;A61K38/00;A61P7/04;C07K14/00;C07K14/755;C12N5/00;C12N15/09;C12P21/02;C12R1/91 |
主分类号 |
C07K14/745 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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