发明名称 |
Cyclosporins and their use as pharmaceuticals. |
摘要 |
Cyclosporins wherein the residue at the 1-position (typically -MeBmt- or -dihydro-MeBmt-) is 3 min O-acylated or 3 min -oxo or -C1-4alkoxyimino substituted, or wherein the residue at the 2-position is beta -O-acyl or beta -oxo substituted, or wherein the residue at the 2-position is -Ile-, or wherein the residue at the 11-position is -MeAla-, -MeIle- or -MealloIle- as well as various naturally occurring cyclosporins/dihydro-derivatives thereof, are useful in reversing resistance to chemotherapy, in particular resistance to cytostatic or anti-neoplastic therapy. Various of these cyclosporins and intermediates for their production are novel. Intermediates wherein the residue (e.g. -MeBmt-, -dihydro-MeBmt- etc.) at the 1-position is 8 min -alkoxy of 7 min -desmethyl-7 min -hydrocarbyl substituted are novel and useful as immunosuppressants, anti-inflammatory and anti-parasitic agents.
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申请公布号 |
EP0296122(A2) |
申请公布日期 |
1988.12.21 |
申请号 |
EP19880810403 |
申请日期 |
1988.06.14 |
申请人 |
SANDOZ AG;SANDOZ-PATENT-GMBH;SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. |
发明人 |
BOLLINGER, PIETRO;BOLSTERLI, JOHANN JAKOB;BOREL, JEAN-FRANCOIS;KRIEGER, MANFRED;PAYNE, TREVOR GLYN;TRABER, RENE P.;WENGER, ROLAND |
分类号 |
A61K38/00;A61P29/00;A61P31/04;A61P31/12;A61P33/02;A61P35/00;A61P35/02;A61P37/06;C07K1/113;C07K7/64 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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