| 摘要 |
PURPOSE:To obtain an antitumor agent having excellent effect against a wide variety of tumors, by using a sulfated polysaccharide and a non-steroidal antiestrogenic agent as active components. CONSTITUTION:The objective agent contains a sulfated polysaccharide (e.g. heparin, low-molecular weight heparin or DS4152) and a non-steroidal antiestrogenic agent (e.g. clomifene, nafoxidine or tamoxifen) as active components. The antitumor agent exhibits the activity to inhibit the arterialization by the combined use of the sulfated polysaccharide and remarkably improves the antitumor effect of the antiestrogenic agent. Furthermore, it exhibits excellent effect against hormone-independent solid tumor. It is administered preferably at a daily rate of 20-40mg of antiestrogenic agent and 1-10mg of sulfated polysaccharide for adult.
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