Pyrazoline derivatives and agents for treating cerebrovascular diseases containing the same as active ingredient.

摘要

This invention relates to new 2-pyrazoline derivatives represented by the following general formula (A): <CHEM> ( wherein R<1> denotes a pyridyl, a pyrazyl or an alkoxyl group; and R<2> stands for hydrogen atom, an alkyl, a pyridyl, a furyl, phenyl or a substituted phenyl group ), and to a process for producing the same. This invention also relates to agents for treating cerebrovascular diseases containing, as active ingredients, a 2-pyrazoline derivative represented by the following general formula (G): <CHEM> ( wherein R<3> denotes hydrogen atom, an alkyl, acetyl, an alkoxycarbonyl, an amino, benzoyl, a substituted benzoyl, a pyridylcarbonyl, a furylcabonyl, a thienylcarbonyl, a pyrazylcarbonyl, an N-substituted carbamoyl, an N-substituted thiocarbamoyl, or carboxyl group; and R<4> stands for hydrogen atom, an alkyl, a pyridyl, a thienyl, a furyl, cyclohexyl, phenyl or a substituted phenyl group ) or a pharmaceutically acceptable salt thereof. Administration of an agent of this invention for treating cerebrovascular diseases copes with cerebral edemata in the acute stage of cerebral apoplexy and regulates the whole-body and intracranial blood circulation, thereby protecting ischemic lesions and minimizing the spread of affected parts.