Novel N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives.

摘要

Novel N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives of formula <CHEM> wherein: A<1>=A<2>-A<3>=A<4> is -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH or -CH=CH-CH=N-; R is hydrogen or C1-6alkyl; R<1> is furanyl substituted with C1-6alkyl, pyrazinyl, thiazolyl, or imidazolyl optionally substituted with C1-6alkyl; L is C3-6alkenyl optionally substituted with Ar<3>, or L is a radical of formula -Alk-R<3>, -Alk-O-R<4>, -Alk-N-(R<5>)-R<6>, -Alk-Z-C(=O)-R<7> or -CH2-CH(OH)-CH2-O-R<9>; the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, which compounds are anti-histaminic agents; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.