| 摘要 |
NEW MATERIAL:A compound (salt) expressed by formula I (R<1> and R<2> are H, alkyl, cycloalkyl, etc.; R<3> is H, lower alkyl, aralkyl, etc.; R<4> is lower alkyl, cycloalkyl, etc.; R<5> is H, lower alkyl, etc.; R<6> is H, lower alkyl or aralkyl). EXAMPLE:N-(2-Oxo-5-octyl-3-tetrahydrofuranyl)-L-alanyl-L-proline benzyl ester. USE:A remedy and preventive agent against hypertension. PREPARATION:For example, a 2-oxo-3-halotetrahydrofuran expressed by formula II (X is halogen) is reacted with amino acid esters, such as alanine esters, and the resultant product is then hydrolyzed to provide a compound expressed by formula III (R<8> is the same kind as that of R<3>), which is subsequently reacted with an amino acid ester expressed by formula IV (R<9> is the same kind as that of R<6>), such as L-proline ester, to afford the aimed compound expressed by formula I.
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