BASIC OXIME ETHERS AND A PROCESS FOR PREPARING SAME

摘要

The invention relates to new basic oxime ethers of the general Formula (I) (I) and pharmaceutically acceptable acid addition salts thereof, a process for their preparation and pharmaceutical compositions comprising the same. In the general Formula (I) A) if n is 4, A1) R stands for phenyl, A is trimethylene and R1 and R2 each stand for isopropyl or together with the adjacent nitrogen atom form a N-phenyl-piperazino group; or A2) R stands for phenyl, A is ethylene and R1 and R2 each stand for isopropyl; or A3) R stands for phenyl, A is -CH2-CH(CH3)-and R1 and R2 each stand for methyl; or A4) R stand for 4-chloro-phenyl, A is trimethylene and R1 and R2 each represent isopropyl; or A5) R stands for 4-chloro-phenyl, A is ethylene and R1 and R2 each stand for methyl; or B) if n is 5, B1) R stands for phenyl, A is ethylene and R1 and R2 are identical and each stand for methyl or isopropyl; or B2) R stands for phenyl, A is -CH2-CH(CH3)-and R1 and R2 are methyl; or B3) R stand for 3-chloro-phenyl, A is trimethylene and R1 and R2 together with the adjacent nitrogen atom form a N-benzyl-piperazino group; or C) if n is 6, C1) R stands for phenyl, A is trimethylene and R1 and R2 each stand for methyl; or C2) R stands for phenyl, A is ethylene and R1 and R2 each stand for isopropyl; with the proviso that if n is 5 and R is phenyl, and A is ethylene and R1 and R2 each are isopropyl, the compound of the general Formula (I) is of Z,E configuration and in all the other cases the compound of the general Formula (I) is of E,E configuration. The compounds of the general Formula (I) can be used in therapy due to their narcosis potentiating, analgesic and anitarrhytmial effect.