| 摘要 |
PURPOSE:To make into perfect sphere and facilitate handling and impregnation and application of medicine by a method wherein a system consisting of clay particles having specified particle diameter or less, the specified amount of binder and specified moisture content based on the solid content is mixed by stirring so as to granulate by rolling into porous granules, the maximum diameters of which lie within the range of specified values. CONSTITUTION:Clay is processed to be ground into fine particles, the diameter of which is 150mum or less. Next, the resultant fine clay particles are bonded to one another so as to obtain specified pills. The specially preferable binder is selected from water-soluble binder or water-dispersible binder. The desirable loadings of the binder based on the clay particle lie within the range of 0.1-10wt.%. In addition, during granulation, the moisture content in the system performs an important role excluding fine clay particle and binder. The moisture content based on the weight of solid content is set to be within the range of 3-50wt.%. Next, the mixture of the above-mentioned clay particles, binder and moisture is mixed by stirring and granulated into granules. At this time, the diameter of granule is made to be 170-840mum.
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