PEPTIDE, PROCESS FOR PREPARATION THEREOF AND USE THEREOF

摘要

Peptides of the formula wherein R1 is hydrogen or acyl, R2 is hydrogen or lower alkyl, R3 and R6 are each carboxy, protected carboxy, carbamoyl or hydroxymethyl, R4 is hydrogen, lower alkyl or hydroxy(lower)alkyl, R5 is hydrogen, carboxy, protected carboxy, carbamoyl, carboxy or protected carboxy(lower)alkyl, or hydroxy(lower)alkyl, R7 is hydrogen or an amino protective group, and n is an integer 0 or 1, with proviso that in the restricted case that each of R3 and R6 is not simultaneously hydroxymethyl, R4 or R5 should be always hydroxy(lower)alkyl, and their pharmaceutically acceptable salts can be used in the therapeutic treatment of infectious diseases caused by pathogenic microorganisms, especially gram-negative bacteria and gram-positive bacteria and fungi.