| 摘要 |
<p>INDANE DERIVATIVES AND METHOD OF TREATMENT The present invention relates to indane derivatives with the following formula: I wherein R1 is H, Halogen, an alkyl group having from one to three carbon atoms inclusive, methoxy, a methylthio-group, or a trifluoromethyl group, n is 2 - 4, X is O or S, Y is O, CH2 or N-R2, where R2 is hydrogen or an (1-6 C) alkyl, (1-6 C) alkenyl or cycloalkyl-methyl group having from three to six carbon atoms, Z is -(CH2)n-, n is 2 or 3 or Z is 1,2-phenylene optionally substituted with halogen or trifluoromethyl or Z = 1,2-C6H4CO- (to form a quinazolidinone or -thione ring system). U = N or C. Each compound exists as geometric isomers and each of these as a pair of optical isomers; and the separation and isolation of these are also within the Moreover, pharmaceutically acceptable acid addition salts of the compounds of Formula I are within the scope of the present invention. Pharmaceutical compositions containing a compound of Formula I or a salt thereof as an active ingredient, and methods for the treatment of hypertension and other cardiovascular diseases as well as anxiety, by administration of a therapeutically active amount of one of the compounds of Formula I to a living animal body, including human beings, fall within the scope of the present invention.</p> |
