| 摘要 |
PURPOSE:To obtain a slowly releasing buccal preparation to be applied to oral mucosa and capable of continuing the effect of the drug over a long period, by triturating a systemic drug in a water-soluble polymeric substance, adding a water-soluble polymer to the mixture and forming the obtained mixture by conventional method. CONSTITUTION:A drug having systemic action, e.g. mono-, di- or trinitroglycerol, dinitroisosorbide, insulin, isoproterenol or propranolol hydrochloride is triturated in a water-soluble polymeric substance, a water-soluble polymer is added to the obtained triturate, an additive (e.g. an excipient, lubricant or flavor) is added according to the need and the mixture is formed by conventional method to obtain the objective slowly releasing buccal preparation. The water-soluble polymeric substance is preferably hydroxypropyl cellulose, polyvinyl pyrrolidone, pullulan, etc., having an adhesivity characterized by an adhesive strength of 0.5-20g/mm<2> (measured at an elongation rate of 20m/min) and a retention power of 0.02-0.2sec/g (measured after pressing with a weight of 400g).
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