| 摘要 |
Ointment compsns., esp. for treating allergic and vasomotor rhinitis, contain (a) at least one steroid (I) of the 16-methyl-1,4-pregnadiene-3,20-dione series and (b) an ointment base comprising mainly a physiologically acceptable component (II) which is liq. or semi-liq. at body temp. and is capable of reducing surface tension. (I) is pref. dexamethasone (Ia) or its derivs., e.g. the t-butyl acetate, or beclomethasone (Ib) or its derivs., e.g. the 21-acetate or dipropionate. (II) is a polyalkylene glycol, esp. a polyethylene glycol (PEG) mixt., opt. mixed with a higher fatty alcohol. The compsns. may also contain preservatives and/or NaCl. ADVANTAGE - Unlike conventional nasal sprays, the ointments do not cause drying of the nasal mucosa.
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