| 摘要 |
Fluorescent indicator dyes for calcium ions of the formulae:
<CHEM>
or
<CHEM>
wherein
R<1> is -H, -CH3, -F, -Cl or -Br;
R<2> is -H, -CH3, -F, -Cl, -Br, or C1-C4 alkoxy;
R<3> and R<3a> are independently H or -CO2H, -CO2R<4>, -CONR<5>R<6>, -SO3H, -SO2NR<5>R<6>, -SO2CF3, -COCH3, or -CN, or
R<3> and R<3a> together are -(CO)NR<5>(CO)-;
R<4> is alpha-acyloxyalkyl or a physiologically acceptable esterifying group;
R<5> and R<6> are independently -H, methyl, or ethyl;
Z is an aromatic or heteroaromatic system coupled to the 5 position of one 2-aminophenoxy ring through a trans ethylenic linkage, wherein the ethylenic linkage may itself be part of an aromatic or heteroaromatic ring system;
W is H and X is H; or
W and X together are O, or NR<5>;
Y is H; Y min is H (unless A is NR<5>, O, or S); or
Y and Y min together are NR<5> and A is C;
A and A min are independently C, N, O, or S;
D is O, N, NH, or N alkyl;
Q is a double bond when D is N and a single bond otherwise; and
R<7> is H and R<8> is H or
R<7> and R<8>, together with heteroatom D, the carbon adjacent R<7>, and the phenyl ring adjacent to R<8>, form a quinoline ring system (D=N, Q=double bond). |
