Process for the preparation of azolylether ketones

摘要

The application relates to a process for the preparation of azolylether ketones of the general formula I, in which R<1> represents chlorine, bromine, phenyl, alkyl having from 1 to 3 carbon atoms or nitro, R<2> represents alkyl having from 1 to 4 carbon atoms, phenyl or phenyl substituted by chlorine, A represents the grouping = CH- or represents a nitrogen atom, and n represents 0, 1, 2 or 3, where ether ketones of the general formula IV, in which R<1>, R<2> and n have the abovementioned meanings, are reacted, at a temperature of 80-140@C, with equimolar quantities, or at most with a 25 mol% excess, of a halogenating agent, preferably sulphuryl chloride, the haloether ketones, obtained in this way or by any other method, of the general formula II, in which R<1>, R<2> and n have the abovementioned meanings, and X represents chlorine or bromine, are reacted with azoles of the general formula III, in which A has the abovementioned meaning, in a molar ratio of 1:2 at a temperature of 100-180@C, and the azolylether ketones are isolated from the reaction mixture by washing with water or with organic solvents, or by separation.