发明名称 |
Process for preparing 6-/D(-)-Alpha-(4-ethyl-2,3-dioxo-1-piperazine-carboxamido)-phenylacetamido/pennicillanic acid. |
摘要 |
<p>Disclosed is a process for preparing 6-[D(-)-alpha-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-phenylacetam ido] penicillanic acid as well as pharmaceutically acceptable alkali metal salts thereof of the formula (I) <CHEM> wherein A represents a hydrogen atom, a sodium atom or a potassium atom, wherein active thioesters of 4-ethyl-2,3-dioxo-1-piperazinecarboxylic acid of the formula (II) <CHEM> wherein R represents a 2-mercaptobenzimidazole radical, 2-mercaptobenzoxazole radical and preferably 2-mercaptobenzothiazole radical, is condensed with silylated form of 6-[D(-)-alpha-aminophenylacetatamido] penicillanic acid of the formula (III) <CHEM> The compound of the formula II is a novel compound. h</p> |
申请公布号 |
EP0294789(A1) |
申请公布日期 |
1988.12.14 |
申请号 |
EP19880109147 |
申请日期 |
1988.06.08 |
申请人 |
KRKA, TOVARNA ZDRAVIL, N.SOL.O |
发明人 |
ZUPET, PAVEL;VITEZIC, NATALIJA |
分类号 |
C07D499/04;A61K31/43;A61P31/04;C07D403/06;C07D413/06;C07D417/06;C07D417/12;C07D499/00;C07D499/64;C07D499/68 |
主分类号 |
C07D499/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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