| 摘要 |
NEW MATERIAL:A compound expressed by formula I (R<1> is 2-6C alkanoyl or methylthioacetyl; R<2> is H, acetonyl, 2-propynyl, 2-5C alkoxycarbonyl, etc.; R<3> is H or methyl; X is H or halogen; Y is H or methyl; the bond between the 1- and the 2-positions may be double bond). EXAMPLE:21-Deoxyhydrocortisone 17alpha-butyrate 21-thiol. USE:An anti-inflammatory agent. PREPARATION:For example, a 21-acetylthiosteroid expressed by formula II is hydrolyzed with a base, such as hydrazine, in tetrahydrofuran at -20-+5 deg.C temperature to provide a compound expressed by formula III, which is then reacted with an acetonyl halide, etc., in the presence of a base to afford the aimed compound expressed by formula I.
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