| 摘要 |
NEW MATERIAL:3-Aminoazetidin-2-one of formula I . USE:A synthetic intermediate of pharmaceuticals such as azthreonam which is an antibiotic beta-lactam compound. PROCESS:The compound of formula III is prepared by reducing the compound of formula II (R1 and R2 are H, amino, or OH-protecting group) preferably in the presence of a Raney nickel catalyst, etc. When R1 and R2 of the resultant compound of formula III are not H, the objective compound of formula I can be obtained by removing the protecting groups from the compound of formula III. The starting compound of formula II is preferably 2,2-dimethyl-7-azido-8-oxo-1- aza-3-oxabicyclo[4,2,0]octane of formula IV. |
