Tissue plasminogen activator analogs having modified growth factor domains.
摘要
<p>Tissue plasminogen activator analogs containing the growth factor domain of native t-PA, the domain having at least one cysteine residue replaced with another amino acid. The t-PA analogs may further contain a variety of substitutions and/or modifications. Pharmaceutical compositions containing one or more of the t-PA analogs along with a physiologically acceptable carrier or diluent are also disclosed.</p>
申请公布号
EP0293936(A2)
申请公布日期
1988.12.07
申请号
EP19880108951
申请日期
1988.06.03
申请人
ZYMOGENETICS INC.;NOVO INDUSTRI A/S;EISAI CO., LTD.