| 摘要 |
Compounds of general formula I <CHEM> wherein, Ar represents a 1-naphthyl group, a 2-naphthyl group, a 2,3-dihydro-1H-inden-4(or 5)-yl group, a 2-furanylmethyl group, a 2-pyridinyl group, a phenyl group or a phenyl substituted by one to three substituents wherein the or each substituent independently represents a loweralkyl group, a loweralkoxy group, a diloweralkylamino group, a cyano group, a loweralkylthio group, a loweralkylsulfinyl group, a loweralkylsulfonyl group, an acyl group, an acylamino group, an aminocarbonyl group, a diloweralkylaminoloweralkoxy group, a trifluoromethyl group, a nitro group or a halogen atom; X represents a thio group, a sulfinyl group, a sulfonyl group or an oxygen atom; d represents zero or one; B represents a carbonyl group, a thioxomethyl group or a cyanoiminomethyl group; each of n, m and p independently represents an integer from 2 to 6 inclusive; each of Z and W independently represent an R group or a <CHEM> group with the proviso that when Z represents R, W represents a -(CH2)m-NR<1>R<2> group and when Z represents (CH2)m-NR<1>R<2>, W represents R; each of R, R<1>, R<2>, R<3> and R<4> independently represents a hydrogen atom, a loweralkyl group, a cycloalkyl group, a phenyl group or a phenylloweralkyl group wherein phenyl may be substituted by one to three radicals wherein each radical independently represents a loweralkyl group, a loweralkoxy group, a cyano group, a trifluoromethyl group, a nitro group or a halogen atom or each of R<1> and R<2>, and R<3> and R<4> may, together with the adjacent nitrogen atom form the heterocyclic ring structure 1-homopiperidinyl, 1-piperidinyl, 4-morpholinyl, 1-pyrrolidinyl, 1-piperazinyl, or 4-substituted-1-piperazinyl; with the further proviso that some meanings given for the symbols must not be realized simultaneously, as indicated specifically in claim 1, or the pharmaceutically acceptable salts thereof are useful in the treatment of cardiac arrhythmia. |
