| 摘要 |
<p>PURPOSE:To facilitate the high-efficiency recovery of 5-chloro-2-methyl-4- isothiazoline-3-one by adding a host compound to a mixture thereof with 2- methyl-4-isothiazoline-3-one to form a clathrate of the former. CONSTITUTION:A mixture of 5-chloro-2-methyl-4-isothiazoline-3-one of formula I of high antibacterial activity with 2-methyl-4-isothiazoline-3-one of formula II whose antibacterial activity is 1/10 of the former, as a by-product is obtained, for example, by halogenation of beta-thioketoamide in an inert organic solvent such as an acetate ester. A host compound, especially 1,1,6,6-tetraphenyl-2,4- hexadine-1,6-tetraphenyl-2,4-hexadiynediol-1,6, or 1,1-di(2,4-dimethylphenyl)-2- propanol-1 is suitable, is added to the solution mixture and the compound of formula I is separated in the form of a clathrate.</p> |
