| 摘要 |
<p>A doxorubicin/liposome composition which can be reconstituted from a lyophilized form to an injectable liposome suspension having selected liposome sizes in the size range between 0.1 and 0.5 microns showing little tendency to aggregate on storage, and between 85-95 % liposome-entrapped doxorubicin. The composition is prepared by reconstituting a lyophilized doxorubicin/liposome composition to a liposome concentrate, then diluting the concentrate for parenteral injection to treat tumors. The liposome show more uniform biodistribution and drug clearance characteristics.</p> |
