发明名称 |
VERSIONS OF METHOD OF PRODUCING DERIVATIVES OF 4-ACETOXY-3-OXYETHYL-AZETIDI-2-NON |
摘要 |
<p>A process for preparing 4-acetoxy-3-hydroxyethylazetizin-2-one derivative having the general formula (II): <CHEM> wherein R<1> is a protective group for hydroxy group, which comprises reacting the beta -lactam compound having the general formula (I): <CHEM> wherein R<1> is above, R<2>, R<3> and R<4> are a lower alkyl group of C1 to C4, phenyl group or aralkyl group and R is a protective group for N, with acetic anhydride in the organic solvent in the presence of base and then removing the protective group for N. 4-Acetoxy-3-hydroxyethylazetin-2-one derivatives are the useful intermediates for preparing carbapenem beta -lactam antibiotics such as thienamycin and penem beta -lactam antibiotics.</p> |
申请公布号 |
SU1442071(A3) |
申请公布日期 |
1988.11.30 |
申请号 |
SU19853923699 |
申请日期 |
1985.07.03 |
申请人 |
KANEGAFUCHI CHEMICAL IND |
发明人 |
TAKEKHISA OKHASI,JP;KAZUNORI KAN,JP;ISAO SADA,JP;AKIMASA MIYAMA,JP;KIESI VATANABE,JP |
分类号 |
C07D205/08;C07F7/18 |
主分类号 |
C07D205/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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