Chromatographic packings comprising metal oxide/hydroxide reacted with phosphonic acid

摘要

A chromatographic packing material is disclosed comprising a metal oxide/hydroxide particle having chemically bonded to reactive sites on a surface thereof, a monolayer of one or more phosphonic acids. The bond to the metal oxide/hydroxide surface is formed by reaction of the phosphorous-containing group of the phosphonic acid with the metal oxide/hydroxide surface, so that the carbon-containing or non-polar group of the phosphonic acid is oriented away from the metal oxide/hydroxide surface.