摘要 |
PURPOSE:To obtain the titled compound useful as an intermediate for pharmaceuticals, agricultural chemicals, etc., on an industrial scale at a low cost, by fluorinating 1,2-dibromoethane with hydrogen fluoride in the presence of cuprous oxide and a polar aprotic solvent. CONSTITUTION:(A) 1,2-Dibromoethane is made to react with (B) hydrogen fluoride in the presence of (C) cuprous oxide and (D) a polar aprotic solvent (preferably sulfolane or dimethyl sulfoxide) preferably at 100-150 deg.C for 1-6hr to effect selective monofluorination of the raw material A and produce the titled compound useful as a fluoroethylation agent for the synthesis of fungicide. The objective compound can be produced on an industrial scale in high yield at a low cost while suppressing the formation of highly toxic vinyl bromide caused by dehydrobromination reaction. The molar amounts of the components B, C and D per 1mol. of the component A are preferably 1-30, 0.5-1 and 5-10, respectively. |