| 摘要 |
NEW MATERIAL:A 5-fluorouracil derivative expressed by formula I (R<1> is H or lower alkyl; R<2> is 1-20C straight-chain or branched chain alkyl; X is O or single bond) and pharmacologically acceptable salt thereof. EXAMPLE:4-O-Pivaloyloxymethyl-5-fluorouracil. USE:An antitumor agent. PREPARATION:A compound expressed by formula II (M is Na, K, Ag, Hg, etc.; R<3> is a protecting group of hydroxyl group, such as halogeno-lower alkyl or alkyl substituted by 1-3 aryl groups) is reacted with a compound expressed by formula III (Z is halogen, alkylcarbonyloxy, etc.) to provide a compound expressed by formula IV. The protecting group of the hydroxyl group is then eliminated to afford the aimed compound expressed by formula I.
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