FATTORE DI ATTIVAZIONE DI LEUCOCITI NEUTROFILI, PROCEDIMENTO DI PREPARAZIONE, NONCHE' COMPOSIZIONI FARMACEUTICHE CHE LO CONTENGONO

摘要

Neutrophil-activating factor (NAF) is claimed. More specifically it has the qiven complete amino acid sequence. Also claimed is DNA having the nucleotide sequence indicated and equivalents suitable for expression in E.coli of NAF. - The total amino acid sequence of NAF purified from LPS-stimulated human monocytes has been detd. and a gene coding for the main NAF species synthesised and expressed as a recombinant peptide with the same neutrophil-activating properties as its natural homologue.