| 摘要 |
This invention provides a medicament for treating the symptoms of schizophrenia which comprises the use of an effective amount of a compound selected from the group consisting of optically-active or racemic compounds represented by general formula (I), wherein R1 is selected from the group consisting of organic radicals having fused rings, phenyl, pyridyl, (a), (b), (c) and (d), X is oxygen or sulfur, and further substituted derivatives thereof wherein any of the aromatic rings may be substituted with hydroxy, nitro, cyano, azido, amino, acylamino, carboxyamido, trifluoromethyl, sulfate, sulfonamido halogen, hydrocarbyl and hetero atom-substituted hydrocarbyl radicals, wherein said heteroatoms are selected from the group consisting of halogen, nitrogen, oxygen, sulfur and phosphorus and said hydrocarbyl radicals comprise from 1 to 12 carbon atoms, R2, R3 and R4 are each selected from the group consisting of H and OA, A is H or is selected from the group consisting of hydrocarbyl radicals, or (e), R5 is selected from the group consisting of hydrocarbyl radicals and n is 2 or 3; with the proviso that at least one of R2, R3 and R4 is H, that at least one of R2, R3 and R4 is not H and that R2 and R4 are not both OA, except that when R1 is m-hydroxyphenyl, phenyl or 2-thienyl, the compound is optically-active. |
