A cycling biochip sensor adsorber produced by immobilizing a ligand binding protein having high ligand affinity and specificity and capable of reversible denaturation on a substratum. The immobilized binding protein is denatured by heat which induces ligand release and renatured by cooling to ambient temperature regenerating an active biochip sensor. The substratum may be selected from among various solid support structures including semiconductor materials. When the binding protein is immobilized on the insulated gate region of an IGFET, the component so formed is suitable for use as an element of a sensor, when electronic circuitry is provided.
