发明名称 Emulsion compostions for the parenteral administration of sparingly water soluble ionizable hydrophobic drugs
摘要 This disclosure describes quick breaking, in vivo, intravenous, intramuscular, intraarticular fat emulsion compositions which incorporate the use of benzyl alcohol as a consurfactant and/or a cosolvent in combination with materials such as synthetic surfactants, e.g. sorbitan triisostearate, triglycerol diisostearate or triglycerol pentaoleate; naturally occurring vegetable oils, e.g. sesame oil, and soybean oil; natural lecithins such as egg lecithin or soy lecithin; saturated or unsaturated aliphatic acids, e.g. oleic acid, hexanoic acid and linolenic acid; and other excipients such as glycerine, polyvinylpyrrolidone, Pluronic TM F-68 and di- alpha -tocopherol.
申请公布号 US4784845(A) 申请公布日期 1988.11.15
申请号 US19850776306 申请日期 1985.09.16
申请人 AMERICAN CYANAMID COMPANY 发明人 DESAI, NARENDRA R.;SHINAL, EDWARD C.;GANESAN, MADURAI;CARPENTIER, EUGENE A.
分类号 A61K9/10;A61K9/00;A61K9/107;A61K47/00;A61K47/10;A61K47/44;(IPC1-7):A61K31/02;A61K31/08;A61K31/16;A61K31/40 主分类号 A61K9/10
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