| 摘要 |
A controlled release tablet comprising (I) a core, containing as essential components (a) at least one water-soluble pharmaceutically active substance which is dispersed in a water-insoluble, non-digestible polymeric excipient, and (b) a water-insoluble polymeric substance, which is swellable under the influence of water, and (II) a coating essentially of an elastic, water-insoluble and semipermeable diffusion film of a polymer, is presented, which shows a release pattern for the active substance(s) in a programmed rate of approximately zero order.
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