| 摘要 |
2-[2-Hydroxy-4-(substituted)phenyl]piperidines and derivatives thereof of the formula <IMAGE> (I) or a pharmaceutically acceptable acid addition salt thereof, wherein R1 is H, benzyl or certain acyl groups, R2 is H, certain alkyl, alkenyl, alkynyl, hydroxyalkyl, acyl or alkylsulfonyl groups; R3 is H2, O, <IMAGE> and Z is (C1-C13)alkylene or -(alk1)m-O-(alk2)n- where each of (alk1) and (alk2) is (C1-C13)alkylene, provided that the number of carbon atoms in (alk1) plus (alk2) is not greater than 13; each of m and n is 0 or 1; and W is H, pyridyl or optionally substituted phenyl; their use as analgesic agents, intermediates therefor and processes for their preparation. |
