发明名称 |
EXPRESSION AND DIAGNOSTIC USE OF gag ENCODED PEPTIDES WHICH ARE IMMUNOLOGICALLY REACTIVE WITH ANTIBODIES TO LAV. |
摘要 |
Immunologically reactive gag proteins of LAV are expressed in bacterial cells. The gag proteins are encoded by a recombinant plasmid containing procaryotic trancriptional and translational signals for expression, followed downstream by a DNA sequence comprising a portion of the gag region of LAV. Preferred signals for expression are selected from an inducible and/or suppressible operon, such as the trp operon. The gag proteins are isolated from the bacterial host and are utilized in diagnostic assays which detect the presence of LAV antigens or antibodies immunologically reactive with LAV. Further, the proteins produced by the method disclosed may be used as a vaccine against infection by the causitive virus for acquired immune deficiency syndrome. |
申请公布号 |
EP0220234(A4) |
申请公布日期 |
1988.11.09 |
申请号 |
EP19860902680 |
申请日期 |
1986.04.07 |
申请人 |
GENETIC SYSTEMS CORPORATION |
发明人 |
WATANABE, SUSAN, MITSUE;COSAND, WESLEY;MCARDLE, SUSAN;TRAVIS, BRUCE, MCFARLAND;WARD, PAMELA, JUNE |
分类号 |
G01N33/569;A61K39/00;C07H21/04;C07K14/15;C07K14/155;C07K14/16;C12N1/00;C12N1/21;C12N15/00;C12N15/09;C12N15/66;C12P21/00;C12P21/02;C12R1/19 |
主分类号 |
G01N33/569 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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