发明名称 |
Process for preparing griseolic acid derivatives |
摘要 |
Griseolic acid and dihydrodesoxygriseolic acid derivatives having an alkyl or aralkyl group as a substituent on the amino group at the 6-position are prepared by reacting the unsubstituted compound with a compound R7-X (where R7 is alkyl or aralkyl and X is halogen or sulfonyloxy). The group first substitutes and quaternizes the 1-nitrogen atom. The compound is then subjected to an appropriate combination of temperature and pH to cause ring cleavage, rearrangement and ring closure involving the 6-amino group and this quaternized 1-nitrogen to give a 6-alkylamino or 6-aralkylamino derivative.
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申请公布号 |
US4783532(A) |
申请公布日期 |
1988.11.08 |
申请号 |
US19860856586 |
申请日期 |
1986.04.25 |
申请人 |
SANKYO COMPANY LIMITED |
发明人 |
KANEKO, MASAKATSU;KIMURA, MISAKO;MUROFUSHI, YOSHINOBU |
分类号 |
C07H19/02;C07H19/052;(IPC1-7):A61K31/52 |
主分类号 |
C07H19/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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