| 摘要 |
<p>2-¢4-¢(4,4-DIALKYL-2,6-PIPERIDINEDION-1-YL) BUTYL!-1-PIPERAZINYL!PYRIMIDINES 1-¢4-(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl!piperazines with 2-pyrimidyl substituents in the 4- position have been synthesized and demonstrate useful anxiolytic properties. The compound 4,4 dimethyl-1-L4-¢4-(2-pyrimidinyl)-1-piperazinyl!butyl!-2,6-piperidinedione, which has selective anxiolytic activity, constitutes the preferred embodiment of the invention. Background of the Invention Related art can be generalized by compounds of the following structural type: in which n is 4 or 5 and B is a substituted or unsubstituted 2-pyrimidyl moiety. These and related compounds have been prepared as psychotropic agents and are described in: Wu, et al., Journal of Medicinal Chemistry, 15/5, 477-479 (1972). Wu, et al., U.S. Patent No. 3,717,634 patented Feb. 20, 1973. Wu, et al., U.S. Patent No. 3,907,801 patented Sept. 23, 1975. Wu, et al., U.S. Patent No. 3,976,776 patented Aug, 24, 1976.</p> |
