| 摘要 |
PURPOSE:To stably obtain the titled compound useful as a remedy for pancreatopathy in a simple process by treatment in a short time, by adding a specific amount of a water-soluble organic solvent to an aqueous solution of gabexate mesilate in a specific concentration, stirring the mixture and freeze- drying the resultant mixture. CONSTITUTION:A water-soluble organic solvent (e.g. ethanol, methanol, acetone, n-propanol, ethyl acetate or acetonitrile) in an amount of 0.5-10vol./vol.% is added to an aqueous solution of gabexate mesilate in 2-25wt./vol.%, preferably 5-20wt./vol.% concentration and the resultant mixture is stirred and then freeze-dried to afford the aimed gabexate mesilate pharmaceutical. Freeze-drying time can be shortened to half as compared with that of a heat-treating method according to this method. Since the organic solvent is added in the small amount, it can be removed without using a large-sized apparatus.
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