发明名称 NUCLEOSIDES AND NUCLEOSIDE ANALOGUES, PHARMACEUTICAL COMPOSITION AND PROCESSES FOR THE PREPARATION OF THE COMPOUNDS
摘要 A compound of formula (I), wherein the radicals A, X, R<1>, R<2>, and R<3> are defined as follows: A: formula (a) or formula (b); X: (a) O; (b) S; (c) CH2; R<1>: H; alkyl containing 1-3 carbon atoms; -CH=CH2; -CH=CH-CH3; -CH2-CH=CH2; formula (II); -C=CH; R<2>: H; or R<2> constitutes together with R<3> a carbon-carbon bond; R<3>: H; F; Cl; Br; I; N3; CN; C=CH; OH; OCH3; CH2OH; and when R<3> is F; Cl; Br; I; N3; CN; C=CH; OH; OCH3 or CH2OH it may have either the cis-configuration or trans-configuration relative to the hydroxymethyl function at position 4', or R<3> constitutes together with R<2> a carbon-carbon bond, and therapeutically acceptable salts thereof, for use in therapy, in particular for the treatment of HIV virus infections.
申请公布号 AU1689988(A) 申请公布日期 1988.11.04
申请号 AU19880016899 申请日期 1988.04.06
申请人 AKTIEBOLAGET ASTRA-VENT 发明人 ROELF DATEMA;BO FREDRIK OBERG;GORAN BERTIL STENING;BJORN GUNNAR LINDBORG;KARL NILS GUNNAR JOHANSSON;ZSUZANNA MARIA ILONA KOVACS
分类号 C07D239/47;A61K31/505;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7068;A61K31/7072;A61P31/12;C07D239/54;C07H19/06 主分类号 C07D239/47
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